Description
Piperacillin and Tazobactam Injection is available with the branding “AZOPIP 1.125” and is a drug belonging to the class of ‘Antibiotics’, which is used mainly to cure bacterial infections. Piperacillin+tazobactam is prescribed for the treatment of multiple hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (such as diabetic foot infections) and uterine infections. Bacterial infection develops when pathogenic bacteria multiply in the body and make it sick. It can infect any organ of the body and grows very fast.
Piperacillin and Tazobactam Injection has two drugs, i.e., Piperacillin (a β-lactam antibiotic) and Tazobactam (a β-lactamase inhibitor). Piperacillin is a member of the ‘Penicillin antibiotics’ class. It is bactericidal (bacteria-killing) in action against gram-positive and gram-negative aerobic (depending on oxygen for living) and anaerobic (lives in minimal or no oxygen) bacteria. This β-lactam antibiotic works by attaching to penicillin-binding proteins (PBPs) in the bacterial cell wall, preventing the bacteria from forming its protective cell wall.
Tazobactam is an inhibitor of beta-lactamase. Beta-lactamases are the bacterial enzymes that enable bacteria to become multi-resistant to β-lactam antibiotics, including penicillins and cephalosporins. Tazobactam inhibits the degradation of other antibiotics by beta-lactamase enzyme-producing bacteria. In this drug, Piperacillin is inhibited from being destroyed by bacteria by Tazobactam.
Uses of Piperacillin and Tazobactam Injection
- Treatment of Intra-Abdominal Infections: It is used in the treatment of serious intra-abdominal infections by acting on the bacteria causing them.
- Respiratory Tract Infections: It is employed in the treatment of severe respiratory infections, such as pneumonia.
- Skin and Soft Tissue Infections: This injection is employed in the treatment of complicated skin and soft tissue infections, such as surgical wound infections, bites, or diabetic foot infections.
- Urinary tract infections: It can also be used in treating urinary tract infections, to remove the bacteria that cause these infections.
- Gynaecological Infections: It is applied to the treatment of severe infections in women, such as pelvic inflammatory disease and endometritis, by acting against a wide spectrum of bacteria.
Medical Benefits
- Piperacillin is a Penicillin antibiotic. It works through binding to the penicillin-binding proteins (PBPs) within the bacterial cell wall and inhibiting the synthesis of their cell wall.
- Tazobactam is a beta-lactamase inhibitor that inhibits the degradation of other antibiotics by beta-lactamase enzyme-producing microbes.
- In this work, Tazobactam inhibits bacteria from breaking down Piperacillin.
- This injection helps to treat several bacterial infections of the stomach, lungs, skin and uterus.
Directions for Use
- The initial dose of this injection will be given by the doctor.
- Read the label instructions and follow this medicine as directed by the physician.
- Before taking this medicine check if it appears cloudy, has turned colour, or contains particles.
Storage
- Keep this injection in a cool, dry place.
- Do not put it in the sun or heat.
- Tighten the lid tightly after use.
- Keep it away from the reach of the child to avoid an accident.
Precautions
- It can interact with anticoagulants (heparin), antibiotics (tobramycin, vancomycin), gout medications (probenecid), anti-cancer therapies (methotrexate), and anaesthetic agents (vecuronium).
- Do not drink alcohol when on Piperacillin and Tazobactam Injection to avoid nasty side effects like vomiting and nausea.
- Before you start this medicine, inform your doctor if you have cystic fibrosis, kidney disease, seizures, colitis, bleeding disorders, heart or liver conditions, and are on dialysis therapy.
- Pregnant women must be taken cautiously during pregnancy because it crosses the placenta in humans.
- This drug can also influence urine glucose tests; therefore, alert your doctor in advance if you are using it.
Side Effects
- Trouble sleeping
- Diarrhoea
- Headache
- Nausea
- Constipation
Frеquеntly Askеd Quеstions (FAQs)
What is the use of this composition?
It treats life-threatening bacterial infections such as pneumonia, urinary tract infection, and intra-abdominal infection.
Is this injection effective for sepsis?
Yes, it is usually applied in hospitals to treat sepsis due to susceptible bacteria.
Can it cure lung infections?
Yes, it is effective in treating hospital-acquired pneumonia and other serious lung infections.
Is this injection administered for kidney infections?
Yes, it can be used to treat complex urinary tract and kidney infections caused by bacteria.
Does it helps in treating skin and soft tissue infections?
Yes, it is usually used for deep skin infections, diabetic foot ulcers, and cellulitis.
Is this injection administered after surgery?
Yes, it can be administered to prevent or treat postoperative infections, particularly abdominal or pelvic infections.
Is it useful in neutropenic patients?
Yes, it is frequently used to have infections in neutropenic patients (low white blood cells), especially cancer patients.
Can it be used in bone infections (osteomyelitis)?
It can be utilised for bone and joint infections under a doctor’s supervision.
Is the antibiotic good for infections caused by resistant bacteria?
Yes, it is broad-spectrum against many drug-resistant gram-negative and gram-positive bacteria, but not all.
